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Issue 1, 2015
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Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates

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Abstract

A novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates was synthesized and evaluated by photochemical characterization and cell-based assays. The specific responsiveness to the cytoplasmic entry of the probe was implemented by adopting a disulfide linker, whose cleavage under the reducing conditions of the cytoplasm induced the display of a distinctive fluorescence signal.

Graphical abstract: Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates

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Publication details

The article was received on 24 Aug 2014, accepted on 22 Oct 2014 and first published on 22 Oct 2014


Article type: Communication
DOI: 10.1039/C4OB01810A
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Org. Biomol. Chem., 2015,13, 73-76

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    Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates

    H. S. Kim, W. Y. Song and H. J. Kim, Org. Biomol. Chem., 2015, 13, 73
    DOI: 10.1039/C4OB01810A

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