Issue 48, 2014
From the journal:

Organic & Biomolecular Chemistry

Design and synthesis of a mitochondria-targeting carrier for small molecule drugs†

Junyan Han,*ab   Tae Hoon Lee,a   Ching-Hsuan Tung‡a  and  Daniel Y. Lee*ac  

* Corresponding authors

a Department of Translational Imaging, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX, USA

b Kenneth R. Peak Brain and Pituirary Tumor Center, Department of Neurosurgery, Houston Methodist Hospital, 6565 Fannin street, Houston, TX, USA
E-mail: jhan@houstonmethodist.org

c Department of Radiology, Houston Methodist Hospital, 6670 Bertner Ave, Houston, TX, USA
E-mail: dlee@houstonmethodist.org

Abstract

A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.

Graphical abstract: Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

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Article information

DOI
https://doi.org/10.1039/C4OB01981D
Article type
Communication
Submitted
17 Sep 2014
Accepted
27 Oct 2014
First published
30 Oct 2014

Org. Biomol. Chem., 2014,12, 9793-9796

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Design and synthesis of a mitochondria-targeting carrier for small molecule drugs

J. Han, T. H. Lee, C. Tung and D. Y. Lee, Org. Biomol. Chem., 2014, 12, 9793 DOI: 10.1039/C4OB01981D

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