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Issue 46, 2014
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Copper-catalysed α-selective allylic alkylation of heteroaryllithium reagents

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Abstract

2-Allyl-substituted thiophenes and furans are synthesised efficiently in a direct procedure using 2-heteroaryllithium reagents and allyl bromides and chlorides catalysed by ligand-free copper(I). The reactions take place under mild conditions, with excellent α-selectivity, high functional group tolerance and good yields for the SN2 products.

Graphical abstract: Copper-catalysed α-selective allylic alkylation of heteroaryllithium reagents

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The article was received on 05 Sep 2014, accepted on 13 Oct 2014 and first published on 13 Oct 2014


Article type: Communication
DOI: 10.1039/C4OB01896F
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Org. Biomol. Chem., 2014,12, 9321-9323

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    Copper-catalysed α-selective allylic alkylation of heteroaryllithium reagents

    C. Vila, V. Hornillos, M. Fañanás-Mastral and B. L. Feringa, Org. Biomol. Chem., 2014, 12, 9321
    DOI: 10.1039/C4OB01896F

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