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Issue 41, 2014

Base-promoted annulation of α-hydroxy ketones and dimethyl but-2-ynedioate: straightforward access to pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones

Author affiliations

Abstract

A novel and efficient cascade annulation of tertiary α-hydroxy ketones and dimethyl but-2-ynedioate is reported. The reaction, which only requires a base as the promoter, provides a straightforward access to polysubstituted pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones under very mild reaction conditions.

Graphical abstract: Base-promoted annulation of α-hydroxy ketones and dimethyl but-2-ynedioate: straightforward access to pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones

Supplementary files

Article information


Submitted
31 Aug 2014
Accepted
04 Sep 2014
First published
04 Sep 2014

Org. Biomol. Chem., 2014,12, 8128-8131
Article type
Communication
Author version available

Base-promoted annulation of α-hydroxy ketones and dimethyl but-2-ynedioate: straightforward access to pyrano[4,3-a]quinolizine-1,4,6(2H)-triones and 2H-pyran-2,5(6H)-diones

H. He, C. Qi, Y. Ou, W. Xiong, X. Hu, Y. Ren and H. Jiang, Org. Biomol. Chem., 2014, 12, 8128 DOI: 10.1039/C4OB01858C

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