Jump to main content
Jump to site search

Issue 46, 2014
Previous Article Next Article

A review of methods to synthesise 4′-substituted nucleosides

Author affiliations

Abstract

Modified nucleosides have received a great deal of attention from the scientific community, either for use as therapeutic agents, diagnostic tools, or as molecular probes. Perhaps the most difficult position of a nucleoside to modify is the 4′-position. Chemists have developed innovative methods to achieve this in a stereoselective manner to allow incorporation of a variety of functional groups. This review provides a summary of the most commonly used or recently published methods for ribose, deoxy-ribose, 4′-thioribose, and carbocyclics.

Graphical abstract: A review of methods to synthesise 4′-substituted nucleosides

Back to tab navigation

Publication details

The article was received on 10 Jul 2014, accepted on 30 Sep 2014 and first published on 01 Oct 2014


Article type: Review Article
DOI: 10.1039/C4OB01449A
Author version
available:
Download author version (PDF)
Org. Biomol. Chem., 2014,12, 9291-9306

  •   Request permissions

    A review of methods to synthesise 4′-substituted nucleosides

    M. Betson, N. Allanson and P. Wainwright, Org. Biomol. Chem., 2014, 12, 9291
    DOI: 10.1039/C4OB01449A

Search articles by author

Spotlight

Advertisements