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Issue 31, 2014
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Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes

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Abstract

A convenient procedure for the carbonylative synthesis of isoindoloquinazolinones has been developed. Using 1,2-dibromobenzenes and 2-aminobenzyl amine as substrates and palladium as the catalyst, the desired products were isolated in moderate to good yields with the installation of two molecules of carbon monoxide. Notably, this is the first example of carbonylative synthesis of batracylin analogues.

Graphical abstract: Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes

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Article information


Submitted
29 May 2014
Accepted
19 Jun 2014
First published
19 Jun 2014

Org. Biomol. Chem., 2014,12, 5835-5838
Article type
Communication
Author version available

Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes

J. Chen, H. Neumann, M. Beller and X. Wu, Org. Biomol. Chem., 2014, 12, 5835
DOI: 10.1039/C4OB01103A

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