Issue 31, 2014

Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes

Abstract

A convenient procedure for the carbonylative synthesis of isoindoloquinazolinones has been developed. Using 1,2-dibromobenzenes and 2-aminobenzyl amine as substrates and palladium as the catalyst, the desired products were isolated in moderate to good yields with the installation of two molecules of carbon monoxide. Notably, this is the first example of carbonylative synthesis of batracylin analogues.

Graphical abstract: Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes

Supplementary files

Article information

Article type
Communication
Submitted
29 May 2014
Accepted
19 Jun 2014
First published
19 Jun 2014

Org. Biomol. Chem., 2014,12, 5835-5838

Author version available

Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes

J. Chen, H. Neumann, M. Beller and X. Wu, Org. Biomol. Chem., 2014, 12, 5835 DOI: 10.1039/C4OB01103A

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