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Issue 23, 2014

Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins

Author affiliations

Abstract

A traceable linker that is potentially applicable to identification of a target protein of bioactive compounds was developed. It enabled not only thiol-induced cleavage of the linker for enrichment of the target protein but also selective labelling to pick out the target from contaminated non-target proteins for facile identification.

Graphical abstract: Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins

Supplementary files

Article information


Submitted
24 Mar 2014
Accepted
17 Apr 2014
First published
17 Apr 2014

Org. Biomol. Chem., 2014,12, 3821-3826
Article type
Communication

Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins

J. Yamamoto, M. Denda, N. Maeda, M. Kita, C. Komiya, T. Tanaka, W. Nomura, H. Tamamura, Y. Sato, A. Yamauchi, A. Shigenaga and A. Otaka, Org. Biomol. Chem., 2014, 12, 3821 DOI: 10.1039/C4OB00622D

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