Issue 29, 2014
From the journal:

Organic & Biomolecular Chemistry

One-step synthesis of diazaspiro[4.5]decane scaffolds with exocyclic double bonds†

Lidong Li,a   Qiong Hu,a   Pingping Zhou,a   Haifeng Xie,a   Xiaorong Zhang,a   Hao Zhang,a   Yadong Hu,a   Fei Yina  and  Yimin Hu*a  

* Corresponding authors

a Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecular-Based Materials, School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China
E-mail: yiminhu@mail.ahnu.edu.cn
Fax: +86 553 388 3517
Tel: +86 553 386 9310

Abstract

Unactivated yne-en-ynes reacted with a range of substituted aryl halides in the presence of Pd(OAc)2–PPh3 to afford diazaspiro[4.5]decane with exocyclic double bonds. Three carbon–carbon bonds are formed in this domino reaction, which involves highly regioselective C–C coupling and spiro scaffold steps.

Graphical abstract: One-step synthesis of diazaspiro[4.5]decane scaffolds with exocyclic double bonds

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Article information

DOI
https://doi.org/10.1039/C4OB00516C
Article type
Communication
Submitted
07 Mar 2014
Accepted
11 Jun 2014
First published
11 Jun 2014

Org. Biomol. Chem., 2014,12, 5356-5359

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One-step synthesis of diazaspiro[4.5]decane scaffolds with exocyclic double bonds

L. Li, Q. Hu, P. Zhou, H. Xie, X. Zhang, H. Zhang, Y. Hu, F. Yin and Y. Hu, Org. Biomol. Chem., 2014, 12, 5356 DOI: 10.1039/C4OB00516C

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