Issue 23, 2014

Fast imine equilibration and its consequences for the evaluation of dynamic combinatorial libraries

Abstract

An example of the subtle interplay between the intended templation and a very fast reequilibration of a dynamic combinatorial library of imines that occurs upon a solvent change is reported. Such seemingly “irrelevant” details of the procedure like imine dissolution time prior to reduction may dictate the outcome of the whole reaction.

Graphical abstract: Fast imine equilibration and its consequences for the evaluation of dynamic combinatorial libraries

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2014
Accepted
08 Apr 2014
First published
08 May 2014

Org. Biomol. Chem., 2014,12, 3827-3830

Fast imine equilibration and its consequences for the evaluation of dynamic combinatorial libraries

K. Ziach, A. Kulesza and J. Jurczak, Org. Biomol. Chem., 2014, 12, 3827 DOI: 10.1039/C4OB00507D

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