Jump to main content
Jump to site search

Issue 7, 2014
Previous Article Next Article

Electron transport in DNA initiated by diaminonaphthalene donors alternatively bound by non-covalent and covalent association

Author affiliations

Abstract

Covalent conjugation is typically used to fix a potential charge donor to a chosen site for studying either hole or excess electron transport in duplex DNA. A model system based on oligonucleotides containing an abasic site and BrdU was previously developed to provide a rapid method of screening new donors without the need of synthetic chemistry. While this strategy is effective for discovering important lead compounds, it is not appropriate for establishing extensive correlations between molecular structure and donor efficiency as demonstrated with a series of closely related electron donors based on diaminonaphthalene. The non-covalent system accurately identified the ability of the donors to reduce a distal BrdU in DNA, but their varying efficiencies were not recapitulated when attached covalently to an equivalent sequence of DNA. Reduction within the covalent system was not sensitive to the strong donor potentials as consistent with charge recombination dominating the net migration of charge.

Graphical abstract: Electron transport in DNA initiated by diaminonaphthalene donors alternatively bound by non-covalent and covalent association

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Dec 2013, accepted on 02 Jan 2014 and first published on 06 Jan 2014


Article type: Paper
DOI: 10.1039/C3OB42433B
Author version
available:
Download author version (PDF)
Org. Biomol. Chem., 2014,12, 1143-1148
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Electron transport in DNA initiated by diaminonaphthalene donors alternatively bound by non-covalent and covalent association

    N. P. Campbell and S. E. Rokita, Org. Biomol. Chem., 2014, 12, 1143
    DOI: 10.1039/C3OB42433B

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements