Issue 19, 2014
From the journal:

Organic & Biomolecular Chemistry

Discovery of 2′-hydroxychalcones as autophagy inducer in A549 lung cancer cells

Fang-Wu Wang,†a   Sheng-Qing Wang,†b   Bao-Xiang Zhao*b  and  Jun-Ying Miao*a  

* Corresponding authors

a Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, P.R. China
E-mail: bxzhao@sdu.edu.cn, miaojy@sdu.edu.cn
Fax: +86 531 88564464
Tel: +86 531 88366425

b Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China

Abstract

A series of 2′-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 2–7 possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells.

Graphical abstract: Discovery of 2′-hydroxychalcones as autophagy inducer in A549 lung cancer cells

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Article information

DOI
https://doi.org/10.1039/C3OB42429D
Article type
Paper
Submitted
05 Dec 2013
Accepted
26 Feb 2014
First published
26 Feb 2014

Org. Biomol. Chem., 2014,12, 3062-3070

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Discovery of 2′-hydroxychalcones as autophagy inducer in A549 lung cancer cells

F. Wang, S. Wang, B. Zhao and J. Miao, Org. Biomol. Chem., 2014, 12, 3062 DOI: 10.1039/C3OB42429D

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