Issue 13, 2014
From the journal:

Organic & Biomolecular Chemistry

Fluorescent probes for detecting monoamine oxidase activity and cell imaging†

Xuefeng Li,a   Huatang Zhang,b   Yusheng Xie,b   Yi Hu,c   Hongyan Sun*b  and  Qing Zhu*a  

* Corresponding authors

a Institute of Bioengineering, Zhejiang University of Technology, Chaowang Road 18, Hangzhou 310014, China
E-mail: zhuq@zjut.edu.cn
Fax: +86-571-88320781
Tel: +86-571-88320781

b Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China
E-mail: hongysun@cityu.edu.hk

c CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Key Lab of Nuclear Radiation and Nuclear Energy Technology, Center for Multidisciplinary Research, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China

Abstract

A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and β-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 μg mL−1 respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells.

Graphical abstract: Fluorescent probes for detecting monoamine oxidase activity and cell imaging

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C3OB42326C
Article type
Communication
Submitted
21 Nov 2013
Accepted
25 Jan 2014
First published
28 Jan 2014

Org. Biomol. Chem., 2014,12, 2033-2036

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Fluorescent probes for detecting monoamine oxidase activity and cell imaging

X. Li, H. Zhang, Y. Xie, Y. Hu, H. Sun and Q. Zhu, Org. Biomol. Chem., 2014, 12, 2033 DOI: 10.1039/C3OB42326C

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