Issue 6, 2014
From the journal:

Organic & Biomolecular Chemistry

Pd(0)-catalyzed regio- and stereoselective cyclization of alkynes: selective synthesis of (E)-4-(isobenzofuran-1(3H)-ylidene)-1,2,3,4-tetrahydroisoquinolines and aze/oxepinoindoles†

Avanashiappan Nandakumar,a   Selvarangam E. Kiruthika,a   Kanagaraj Naveena  and  Paramasivan Thirumalai Perumal*a  

* Corresponding authors

a Organic Chemistry Division, CSIR-Central Leather Research Institute, Adyar, Chennai-600020, Tamil Nadu, India
E-mail: ptperumal@gmail.com
Fax: +91 44 24911589
Tel: +91 44 24437223

Abstract

Palladium-catalyzed highly regio- and stereoselective 6-exo-dig and 7-endo-dig cyclization of functionalized propargylic compounds has been developed for the synthesis of (E)-4-(isobenzofuran-1(3H)-ylidene)-1,2,3,4-tetrahydroisoquinolines and aze/oxepinoindoles.

Graphical abstract: Pd(0)-catalyzed regio- and stereoselective cyclization of alkynes: selective synthesis of (E)-4-(isobenzofuran-1(3H)-ylidene)-1,2,3,4-tetrahydroisoquinolines and aze/oxepinoindoles

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Article information

DOI
https://doi.org/10.1039/C3OB42314J
Article type
Communication
Submitted
20 Nov 2013
Accepted
03 Dec 2013
First published
03 Dec 2013

Org. Biomol. Chem., 2014,12, 876-880

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Pd(0)-catalyzed regio- and stereoselective cyclization of alkynes: selective synthesis of (E)-4-(isobenzofuran-1(3H)-ylidene)-1,2,3,4-tetrahydroisoquinolines and aze/oxepinoindoles

A. Nandakumar, S. E. Kiruthika, K. Naveen and P. T. Perumal, Org. Biomol. Chem., 2014, 12, 876 DOI: 10.1039/C3OB42314J

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