Issue 5, 2014
From the journal:

Organic & Biomolecular Chemistry

Chiral Brønsted acid-catalyzed enantioselective addition of indoles to ketimines†

Taichi Kano,a   Ryosuke Takechi,a   Ryohei Kobayashia  and  Keiji Maruoka*a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan
E-mail: maruoka@kuchem.kyoto-u.ac.jp
Fax: +81-75-753-4041
Tel: +81-75-753-4041

Abstract

A highly enantioselective addition of indoles to a readily available ketimine was found to be catalyzed by a chiral phosphoric acid. This organocatalytic process represents a rare example of an addition reaction to a non-aromatic ketimine.

Graphical abstract: Chiral Brønsted acid-catalyzed enantioselective addition of indoles to ketimines

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Article information

DOI
https://doi.org/10.1039/C3OB42190B
Article type
Communication
Submitted
05 Nov 2013
Accepted
26 Nov 2013
First published
27 Nov 2013

Org. Biomol. Chem., 2014,12, 724-727

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Chiral Brønsted acid-catalyzed enantioselective addition of indoles to ketimines

T. Kano, R. Takechi, R. Kobayashi and K. Maruoka, Org. Biomol. Chem., 2014, 12, 724 DOI: 10.1039/C3OB42190B

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