Issue 48, 2013
From the journal:

Organic & Biomolecular Chemistry

Organocatalyzed stereospecific C–C bond formation of β-lactams†

Sachin A. Pawar,a   Saba Alapour,a   Sibusiso Khanyase,a   Zamani E. D. Cele,a   Srinivas Chitti,a   Hendrik G. Kruger,a   Thavendran Govender*a  and  Per I. Arvidsson*ab  

* Corresponding authors

a Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, South Africa
E-mail: govenderthav@ukzn.ac.za
Tel: +27 312601845

b Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
E-mail: per.arvidsson@scilifelab.se
Tel: +46 852481398

Abstract

Herein, we report the development of mild, organocatalyzed routes to novel carbapenam derivatives through aldol, Mannich and Michael C–C bond forming reactions.

Graphical abstract: Organocatalyzed stereospecific C–C bond formation of β-lactams

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Article information

DOI
https://doi.org/10.1039/C3OB41858H
Article type
Communication
Submitted
11 Sep 2013
Accepted
01 Nov 2013
First published
04 Nov 2013
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2013,11, 8294-8297

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Organocatalyzed stereospecific C–C bond formation of β-lactams

S. A. Pawar, S. Alapour, S. Khanyase, Z. E. D. Cele, S. Chitti, H. G. Kruger, T. Govender and P. I. Arvidsson, Org. Biomol. Chem., 2013, 11, 8294 DOI: 10.1039/C3OB41858H

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