Issue 42, 2013
From the journal:

Organic & Biomolecular Chemistry

One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization†

Yulin Tian,ab   Jianguo Qi,b   Chenbin Sun,b   Dali Yin,ab   Xiaojian Wang*ab  and  Qiong Xiaob  

* Corresponding authors

a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P.R. China
E-mail: wangxiaojian@imm.ac.cn
Fax: +86 10 63165248
Tel: +86 10 63165248

b Department of Medicinal Chemistry, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P.R. China

Abstract

An efficient, one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction, intramolecular cyclization and isomerization has been developed. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.

Graphical abstract: One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

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Article information

DOI
https://doi.org/10.1039/C3OB41680A
Article type
Communication
Submitted
16 Aug 2013
Accepted
13 Sep 2013
First published
13 Sep 2013

Org. Biomol. Chem., 2013,11, 7262-7266

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One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

Y. Tian, J. Qi, C. Sun, D. Yin, X. Wang and Q. Xiao, Org. Biomol. Chem., 2013, 11, 7262 DOI: 10.1039/C3OB41680A

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