Issue 42, 2013
From the journal:

Organic & Biomolecular Chemistry

A selective fluorescent chemosensor for phosphoserine†

Chad M. Cooley,a   Kenneth S. Hettie,a   Jessica L. Klockow,a   Shana Garrisona  and  Timothy E. Glass*a  

* Corresponding authors

a Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, MO 65211, USA
E-mail: GlassT@missouri.edu
Fax: +1 573-882-2754
Tel: +1 573-882-3813

Abstract

A fluorescent chemosensor for the detection of phosphoserine is reported. The ditopic sensor features a phosphate-coordinating zinc(II)–dipicolylamine (Zn2+–DPA) unit tethered to an amine-binding coumarin aldehyde fluorophore. With phosphoserine, the sensor demonstrates a 30-fold fluorescence enhancement under buffered aqueous conditions.

Graphical abstract: A selective fluorescent chemosensor for phosphoserine

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Article information

DOI
https://doi.org/10.1039/C3OB41677A
Article type
Paper
Submitted
16 Aug 2013
Accepted
18 Sep 2013
First published
19 Sep 2013
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2013,11, 7387-7392

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A selective fluorescent chemosensor for phosphoserine

C. M. Cooley, K. S. Hettie, J. L. Klockow, S. Garrison and T. E. Glass, Org. Biomol. Chem., 2013, 11, 7387 DOI: 10.1039/C3OB41677A

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