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Issue 39, 2013
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Cobalt-catalyzed oxidative [3 + 2] cycloaddition reactions: an efficient synthesis of pyrrolo- and imidazo-[2,1-a]isoquinolines

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Abstract

A cobalt-catalyzed oxidative [3 + 2] cycloaddition cascades of dihydroisoquinoline esters with nitroolefins or N-sulfuryl aldimines were developed at room temperature. A multi-component reaction for the synthesis of 5,6-dihydroimidazo[2,1-a]isoquinolines were also realized under almost identical conditions. This method is particularly suitable for the synthesis of tricyclic nitrogen heterocycles due to its simple manipulation, wide scope of the reaction substrates and excellent regioselectivity.

Graphical abstract: Cobalt-catalyzed oxidative [3 + 2] cycloaddition reactions: an efficient synthesis of pyrrolo- and imidazo-[2,1-a]isoquinolines

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Publication details

The article was received on 11 Jul 2013, accepted on 10 Aug 2013 and first published on 14 Aug 2013


Article type: Communication
DOI: 10.1039/C3OB41424H
Org. Biomol. Chem., 2013,11, 6691-6694

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    Cobalt-catalyzed oxidative [3 + 2] cycloaddition reactions: an efficient synthesis of pyrrolo- and imidazo-[2,1-a]isoquinolines

    C. Feng, J. Su, Y. Yan, F. Guo and Z. Wang, Org. Biomol. Chem., 2013, 11, 6691
    DOI: 10.1039/C3OB41424H

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