Issue 32, 2013

An approach to hyperolactone C and analogues using late stage conjugate addition on an oxonium ylide-derived spirofuranone

Abstract

A stereocontrolled synthesis of norphenyl hyperolactone C together with its utility as a direct precursor to the anti-HIV agent hyperolactone C and analogues by addition of organolithiums, are described. Preliminary studies to access this key building block in a catalytic enantioselective manner are also reported.

Graphical abstract: An approach to hyperolactone C and analogues using late stage conjugate addition on an oxonium ylide-derived spirofuranone

Supplementary files

Article information

Article type
Paper
Submitted
18 Jun 2013
Accepted
20 Jun 2013
First published
12 Jul 2013

Org. Biomol. Chem., 2013,11, 5362-5369

An approach to hyperolactone C and analogues using late stage conjugate addition on an oxonium ylide-derived spirofuranone

D. M. Hodgson, E. Moreno-Clavijo, S. E. Day and S. Man, Org. Biomol. Chem., 2013, 11, 5362 DOI: 10.1039/C3OB41251B

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