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Issue 39, 2013
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Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

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Abstract

A Cu(I)-catalyzed azide–alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin–psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).

Graphical abstract: Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

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Publication details

The article was received on 13 Jun 2013, accepted on 26 Jul 2013 and first published on 29 Jul 2013


Article type: Communication
DOI: 10.1039/C3OB41224E
Org. Biomol. Chem., 2013,11, 6675-6679

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    Novel porphyrin–psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

    D. Kumar, B. A. Mishra, K. P. Chandra Shekar, A. Kumar, K. Akamatsu, R. Kurihara and T. Ito, Org. Biomol. Chem., 2013, 11, 6675
    DOI: 10.1039/C3OB41224E

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