Issue 38, 2013

A facile total synthesis of drospirenone isomers containing 14β-hydrogen configuration

Abstract

A facile strategy for the preparation of two isomeric drospirenones 13 and 16 possessing a 14β-hydrogen was developed, using 3β-hydroxyandrost-5-en-17-one as the starting material. The total synthetic route involves eight steps, giving 2% overall yield. The structures of the main compounds 11, 13, 14 and 16 were determined by single crystal XRD analysis.

Graphical abstract: A facile total synthesis of drospirenone isomers containing 14β-hydrogen configuration

Supplementary files

Article information

Article type
Paper
Submitted
14 Jun 2013
Accepted
03 Aug 2013
First published
07 Aug 2013

Org. Biomol. Chem., 2013,11, 6597-6603

A facile total synthesis of drospirenone isomers containing 14β-hydrogen configuration

W. Wan, G. Ma, W. Gao, J. Wang, L. Li, S. Rao, C. Zheng, H. Jiang, H. Deng and J. Hao, Org. Biomol. Chem., 2013, 11, 6597 DOI: 10.1039/C3OB41211C

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