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Issue 30, 2013
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E-Factor minimized hydrophosphonylation of aldehydes catalyzed by polystyryl-BEMP under solvent-free conditions

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Abstract

An efficient protocol for the hydrophosphonylation of aromatic and aliphatic aldehydes catalyzed by PS-BEMP under solvent-free conditions (SolFC) has been reported. Addition reactions were performed by using equimolar amounts of reagents and the resulting α-hydroxyphosphonates were isolated with simple workup procedures. A large scale protocol for the preparation of a representative α-hydroxyphosphonate 3a has been also set up using a flow reactor.

Graphical abstract: E-Factor minimized hydrophosphonylation of aldehydes catalyzed by polystyryl-BEMP under solvent-free conditions

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Publication details

The article was received on 17 Apr 2013, accepted on 31 May 2013 and first published on 03 Jun 2013


Article type: Paper
DOI: 10.1039/C3OB40767E
Citation: Org. Biomol. Chem., 2013,11, 5042-5046

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    E-Factor minimized hydrophosphonylation of aldehydes catalyzed by polystyryl-BEMP under solvent-free conditions

    T. Angelini, S. Bonollo, D. Lanari, F. Pizzo and L. Vaccaro, Org. Biomol. Chem., 2013, 11, 5042
    DOI: 10.1039/C3OB40767E

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