Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 27, 2013
Previous Article Next Article

Tunable peptoid microspheres: effects of side chain chemistry and sequence

Author affiliations

Abstract

Peptoids are a versatile family of oligomeric synthetic molecules that can be customized for many applications. The submonomer solid-phase synthesis of peptoids allows for quick and inexpensive manufacturing and the selection of side chains is nearly limitless. In addition, peptoids that include chiral, aromatic side chains form stable helical secondary structure that leads to the potential for the formation of supramolecular assemblies. The effects of water solubility, helical content, charge placement, and side chain bulk on microsphere formation were studied for seven peptoid sequences. We found that secondary structure and partial water solubility were essential for microsphere formation. In addition, charge placement and side chain bulk affect both the ability to form microspheres and the diameter of the microspheres.

Graphical abstract: Tunable peptoid microspheres: effects of side chain chemistry and sequence

Back to tab navigation

Supplementary files

Article information


Submitted
20 Mar 2013
Accepted
20 May 2013
First published
21 May 2013

Org. Biomol. Chem., 2013,11, 4459-4464
Article type
Paper

Tunable peptoid microspheres: effects of side chain chemistry and sequence

M. L. Hebert, D. S. Shah, P. Blake, J. P. Turner and S. L. Servoss, Org. Biomol. Chem., 2013, 11, 4459
DOI: 10.1039/C3OB40561C

Social activity

Search articles by author

Spotlight

Advertisements