Issue 15, 2013
From the journal:

Organic & Biomolecular Chemistry

A novel three-component [5 + 1] heterocyclization leading to 2-azafluorenone synthesis and its polyfunctionalizations†

Ying Li,‡a   Wei Fan,‡a   Hai-Wei Xu,a   Bo Jiang,*a   Shu-Liang Wanga  and  Shu-Jiang Tu*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, P. R. China
E-mail: jiangchem@jsnu.edu.cn, laotu@jsnu.edu.cn
Fax: +0086-516-83500065
Tel: +0086-516-83500065

Abstract

An efficient methodology for the synthesis of new and highly functionalized 2-azafluorenones via a three-component domino reaction involving C1-aryl acylation, C3-thiolation, and C4-cyanation has been developed. This domino reaction enables successful assembly of three new sigma bonds including a C–S bond and a C–N bond in a one-pot operation. Features of this strategy include the mild condition, convenient one-pot operation, and short reaction periods (15–30 min).

Graphical abstract: A novel three-component [5 + 1] heterocyclization leading to 2-azafluorenone synthesis and its polyfunctionalizations

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Article information

DOI
https://doi.org/10.1039/C3OB40371H
Article type
Communication
Submitted
20 Feb 2013
Accepted
05 Mar 2013
First published
05 Mar 2013

Org. Biomol. Chem., 2013,11, 2417-2420

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A novel three-component [5 + 1] heterocyclization leading to 2-azafluorenone synthesis and its polyfunctionalizations

Y. Li, W. Fan, H. Xu, B. Jiang, S. Wang and S. Tu, Org. Biomol. Chem., 2013, 11, 2417 DOI: 10.1039/C3OB40371H

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