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Issue 16, 2013
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(+)-Fluorenylethylchloroformate (FLEC) – improved synthesis for application in chiral analysis and peptidomimetic synthesis

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Abstract

An efficient synthesis of the enantiomers of fluorenylethylchloroformate (FLEC) has been achieved that allows the routine application of the reagent for the resolution of chiral amines including unusual amino acids. The utility of the fluorenylethoxycarbonyl (Feoc) group as a chiral Fmoc equivalent, for combined resolution and protection of amino acids, in solid phase peptide synthesis is also shown.

Graphical abstract: (+)-Fluorenylethylchloroformate (FLEC) – improved synthesis for application in chiral analysis and peptidomimetic synthesis

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Publication details

The article was received on 31 Jan 2013, accepted on 20 Feb 2013 and first published on 27 Feb 2013


Article type: Communication
DOI: 10.1039/C3OB40218E
Org. Biomol. Chem., 2013,11, 2571-2573

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    (+)-Fluorenylethylchloroformate (FLEC) – improved synthesis for application in chiral analysis and peptidomimetic synthesis

    M. A. Camerino, D. K. Chalmers and P. E. Thompson, Org. Biomol. Chem., 2013, 11, 2571
    DOI: 10.1039/C3OB40218E

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