Issue 16, 2013
From the journal:

Organic & Biomolecular Chemistry

Palladium(ii)-catalyzed synthesis of functionalized indenones viaoxidation and cyclization of 2-(2-arylethynylphenyl)acetonitriles†

Xuxing Chen,a   Qian He,a   Yuyuan Xiea  and  Chunhao Yang*a  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China
E-mail: chyang@simm.ac.cn

Abstract

A one-pot two-step synthesis of versatile indenones has been developed. This palladium(II)-catalyzed transformation involves generation and condensation of ortho-functionalized 1,2-benzils from 2-(2-arylethynylphenyl)acetonitriles using Ph2SO as the oxidant. The resulting 3-cyanoindenones can be converted to various valuable molecules.

Graphical abstract: Palladium(ii)-catalyzed synthesis of functionalized indenones via oxidation and cyclization of 2-(2-arylethynylphenyl)acetonitriles

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Article information

DOI
https://doi.org/10.1039/C3OB40103K
Article type
Communication
Submitted
18 Jan 2013
Accepted
24 Feb 2013
First published
26 Feb 2013

Org. Biomol. Chem., 2013,11, 2582-2585

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Palladium(II)-catalyzed synthesis of functionalized indenones via oxidation and cyclization of 2-(2-arylethynylphenyl)acetonitriles

X. Chen, Q. He, Y. Xie and C. Yang, Org. Biomol. Chem., 2013, 11, 2582 DOI: 10.1039/C3OB40103K

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