Synthesis and spectroscopic properties of fluorescent 5-benzimidazolyl-2′-deoxyuridines 5-fdU probes obtained from o-phenylenediamine derivatives

Pu Guo; Xiaowei Xu; Xiaoyu Qiu; Yimin Zhou; Shengyong Yan; Changcheng Wang; Chunjiang Lu; Wen Ma; Xiaocheng Weng; Xianzheng Zhang; Xiang Zhou

doi:10.1039/C3OB27519A

Synthesis and spectroscopic properties of fluorescent 5-benzimidazolyl-2′-deoxyuridines 5-fdU probes obtained from o-phenylenediamine derivatives†

Pu Guo,‡^a Xiaowei Xu,‡^a Xiaoyu Qiu,^a Yimin Zhou,^a Shengyong Yan,^a Changcheng Wang,^a Chunjiang Lu,^a Wen Ma,^a Xiaocheng Weng,^a Xianzheng Zhang^a and Xiang Zhou*^ab

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* Corresponding authors

^a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan, P. R. China
E-mail: xzhou@whu.edu.cn
Fax: +86-27-87336380
Tel: +86-27-61056559

^b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, China

Abstract

Fluorescent nucleosides (dU^bmz) with desirable fluorescence quantum yield (Φ) are synthesized from almost non-fluorescent 5-fdU and o-phenylenediamine derivatives. The fluorescence of these nucleosides is quite sensitive to pH and organic solvents. 4-Methoxybenzene-1,2-diamine was used for the detection of 5-fdU among natural nucleosides.

Organic & Biomolecular Chemistry

Synthesis and spectroscopic properties of fluorescent 5-benzimidazolyl-2′-deoxyuridines 5-fdU probes obtained from o-phenylenediamine derivatives†

Abstract

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Synthesis and spectroscopic properties of fluorescent 5-benzimidazolyl-2′-deoxyuridines 5-fdU probes obtained from o-phenylenediamine derivatives

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