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Issue 5, 2013
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Complementary regioselectivity in the synthesis of iminohydantoins: remarkable effect of amide substitution on the cyclization

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Abstract

Complementary regioselective synthesis of iminohydantoins from isocyanoacetamides controlled by the substituent on the amide group has been described. 4-Iminohydantoins were the major products when the starting materials were N-alkyl isocyanoamides, whereas 2-iminohydantoins were the major products with N-aryl isocyanoamides.

Graphical abstract: Complementary regioselectivity in the synthesis of iminohydantoins: remarkable effect of amide substitution on the cyclization

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Publication details

The article was received on 27 Oct 2012, accepted on 04 Dec 2012 and first published on 05 Dec 2012


Article type: Communication
DOI: 10.1039/C2OB27098F
Org. Biomol. Chem., 2013,11, 721-725

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    Complementary regioselectivity in the synthesis of iminohydantoins: remarkable effect of amide substitution on the cyclization

    M. García-Valverde, S. Marcaccini, A. González-Ortega, F. J. Rodríguez, J. Rojo and T. Torroba, Org. Biomol. Chem., 2013, 11, 721
    DOI: 10.1039/C2OB27098F

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