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Issue 4, 2013
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Thiol-inducible direct fluorescence monitoring of drug release

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Abstract

A new bifunctional compound NCC, which undergoes thiol-mediated disulfide cleavage after cell entry, produces a red-shifted fluorescent emission in the cytosol and releases free active DNA alkylating agent CLB into the nucleus, and finally leads to DNA damage and cell death.

Graphical abstract: Thiol-inducible direct fluorescence monitoring of drug release

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Publication details

The article was received on 26 Aug 2012, accepted on 02 Nov 2012 and first published on 02 Nov 2012


Article type: Paper
DOI: 10.1039/C2OB26680F
Org. Biomol. Chem., 2013,11, 580-585

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    Thiol-inducible direct fluorescence monitoring of drug release

    J. Wu, R. Huang, C. Wang, W. Liu, J. Wang, X. Weng, T. Tian and X. Zhou, Org. Biomol. Chem., 2013, 11, 580
    DOI: 10.1039/C2OB26680F

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