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Issue 43, 2012
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Synthesis of chiral bis-oxazines: a preliminary assessment of helical conformational framework

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Abstract

A series of novel naphthalene attached bis-oxazines were synthesized and characterized. The bis-oxazines were studied by VT-NMR analysis to assess the possibility of conformational twist. The bis-oxazine prepared from (l)-methylvalinate show a helical conformational twist in the single crystal X-ray analysis. Three isomers of bis-oxazines were prepared from chiral α-methylbenzyl amines, the meso isomer showed small optical rotation probably indicating the helical conformational twist in the molecule.

Graphical abstract: Synthesis of chiral bis-oxazines: a preliminary assessment of helical conformational framework

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Supplementary files

Article information


Submitted
26 Jun 2012
Accepted
20 Sep 2012
First published
20 Sep 2012

Org. Biomol. Chem., 2012,10, 8579-8582
Article type
Communication

Synthesis of chiral bis-oxazines: a preliminary assessment of helical conformational framework

H. R. Talele and A. V. Bedekar, Org. Biomol. Chem., 2012, 10, 8579 DOI: 10.1039/C2OB26669E

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