Issue 40, 2012

Aminoindanol-based chiral derivatizing agents for the determination of the absolute configuration of carboxylic acids

Abstract

New chiral derivatizing agents have been prepared through a simple, short-step synthesis. The absolute configuration of α-chiral carboxylic acids can be assigned on the basis of the NMR chemical shift difference between diastereomeric esters. Because of the modular structures of the agents, the anisotropic effect could be easily manipulated to afford large chemical shift differences even in polar solvents.

Graphical abstract: Aminoindanol-based chiral derivatizing agents for the determination of the absolute configuration of carboxylic acids

Supplementary files

Article information

Article type
Communication
Submitted
19 Jun 2012
Accepted
22 Aug 2012
First published
23 Aug 2012

Org. Biomol. Chem., 2012,10, 8051-8054

Aminoindanol-based chiral derivatizing agents for the determination of the absolute configuration of carboxylic acids

M. Park, S. Kim and K. Choi, Org. Biomol. Chem., 2012, 10, 8051 DOI: 10.1039/C2OB26168E

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