Issue 39, 2012
From the journal:

Organic & Biomolecular Chemistry

Rationally-designed fluorescent lysine riboswitch probes†

Pradeep Budhathoki,a   Lina F. Bernal-Perez,a   Onofrio Annunziataa  and  Youngha Ryu*a  

* Corresponding authors

a Department of Chemistry, Texas Christian University, 2800 S. University Dr., Fort Worth, TX 76109, USA
E-mail: y.ryu@tcu.edu
Fax: +1-817-257-5851
Tel: +1-817-257-6199

Abstract

Two fluorescent lysine amide analogs, in which the carboxyl end of lysine was covalently attached to dansyl or NBD groups through an ethylene glycol-based linker, were rationally designed and synthesized. Both probes showed high binding affinity to the lysine riboswitch in vitro and their fluorescence intensities decreased by riboswitch binding.

Graphical abstract: Rationally-designed fluorescent lysine riboswitch probes

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Article information

DOI
https://doi.org/10.1039/C2OB26160J
Article type
Communication
Submitted
18 Jun 2012
Accepted
01 Sep 2012
First published
04 Sep 2012

Org. Biomol. Chem., 2012,10, 7872-7874

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Rationally-designed fluorescent lysine riboswitch probes

P. Budhathoki, L. F. Bernal-Perez, O. Annunziata and Y. Ryu, Org. Biomol. Chem., 2012, 10, 7872 DOI: 10.1039/C2OB26160J

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