Issue 38, 2012
From the journal:

Organic & Biomolecular Chemistry

One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature†

Haoyue Xiang,a   Xueyu Qi,ab   Yuyuan Xie,a   Guangyu Xub  and  Chunhao Yang*a  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, P. R. China
E-mail: chyang@mail.shcnc.ac.cn
Fax: +86-21-50806770
Tel: +86-21-50806770

b College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, China

Abstract

An efficient general synthetic approach has been developed to synthesize pyrazole-containing bisphosphonate (N-BPs) esters from chromenone derivatives via a sequential two-step reaction in one pot at ambient temperature in good to excellent yields. This protocol provides a new convenient method to prepare lipophilic bisphosphonate precursors with potential activities.

Graphical abstract: One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2OB25889G
Article type
Paper
Submitted
09 May 2012
Accepted
29 Jul 2012
First published
02 Aug 2012

Org. Biomol. Chem., 2012,10, 7730-7738

Permissions

Request permissions

One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature

H. Xiang, X. Qi, Y. Xie, G. Xu and C. Yang, Org. Biomol. Chem., 2012, 10, 7730 DOI: 10.1039/C2OB25889G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements