Issue 40, 2012
From the journal:

Organic & Biomolecular Chemistry

Asymmetric [3 + 2] annulation of N-protected isatins with but-3-yn-2-one catalyzed by DIOP: facile creation of enantioenriched spiro[furan-2,3′-indoline]-2′,4(5H)-dione†

Zhong Liana  and  Min Shi*a  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P.R. China
E-mail: mshi@mail.sioc.ac.cn

Abstract

DIOP catalyzed highly enantioselective [3 + 2] annulation of N-protected isatins with but-3-yn-2-one has been disclosed, allowing the synthesis of enantioenriched spiro[furan-2,3′-indoline]-2′,4(5H)-dione in moderate yields along with good to high enantioselectivities under mild conditions.

Graphical abstract: Asymmetric [3 + 2] annulation of N-protected isatins with but-3-yn-2-one catalyzed by DIOP: facile creation of enantioenriched spiro[furan-2,3′-indoline]-2′,4(5H)-dione

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Article information

DOI
https://doi.org/10.1039/C2OB25801C
Article type
Communication
Submitted
26 Apr 2012
Accepted
10 Aug 2012
First published
14 Aug 2012

Org. Biomol. Chem., 2012,10, 8048-8050

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Asymmetric [3 + 2] annulation of N-protected isatins with but-3-yn-2-one catalyzed by DIOP: facile creation of enantioenriched spiro[furan-2,3′-indoline]-2′,4(5H)-dione

Z. Lian and M. Shi, Org. Biomol. Chem., 2012, 10, 8048 DOI: 10.1039/C2OB25801C

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