Issue 29, 2012
From the journal:

Organic & Biomolecular Chemistry

Iminosugar–ferrocene conjugates as potential anticancer agents†

Audrey Hottin,a   Faustine Dubar,b   Agata Steenackers,c   Philippe Delannoy,c   Christophe Biotc  and  Jean-Bernard Behr*a  

* Corresponding authors

a Université de Reims Champagne-Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, UFR des Sciences Exactes et Naturelles, 51687 Reims Cedex 2, France
E-mail: jb.behr@univ-reims.fr
Fax: +33 326913166
Tel: +33 326913238

b Université Lille Nord de France, Université Lille 1, Unité de Catalyse et Chimie du Solide, CNRS UMR 8181, 59652 Villeneuve d'Ascq Cedex, France

c Université Lille Nord de France, Université Lille 1, Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, IFR 147, 59650 Villeneuve d'Ascq Cedex, France

Abstract

We prepared a series of new iminosugar–ferrocene hybrids displaying potent inhibition of fucosidase (bovine kidney) and inactivation of MDA-MB-231 breast cancer cells proliferation at low micromolar concentrations. The synthetic route brought to light an unprecedented isomerisation of a 2-ethanalylpyrrolidine.

Graphical abstract: Iminosugar–ferrocene conjugates as potential anticancer agents

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Article information

DOI
https://doi.org/10.1039/C2OB25727K
Article type
Paper
Submitted
12 Mar 2012
Accepted
08 Jun 2012
First published
13 Jun 2012

Org. Biomol. Chem., 2012,10, 5592-5597

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Iminosugar–ferrocene conjugates as potential anticancer agents

A. Hottin, F. Dubar, A. Steenackers, P. Delannoy, C. Biot and J. Behr, Org. Biomol. Chem., 2012, 10, 5592 DOI: 10.1039/C2OB25727K

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