Issue 30, 2012

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

Abstract

Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal–Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature.

Graphical abstract: Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

Supplementary files

Article information

Article type
Communication
Submitted
24 Feb 2012
Accepted
21 Mar 2012
First published
21 Mar 2012

Org. Biomol. Chem., 2012,10, 5774-5779

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

P. B. Cranwell, M. O'Brien, D. L. Browne, P. Koos, A. Polyzos, M. Peña-López and S. V. Ley, Org. Biomol. Chem., 2012, 10, 5774 DOI: 10.1039/C2OB25407G

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