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Issue 30, 2012
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“Frustrated Lewis pair” hydrogenations

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This perspective article discusses developments of metal-free hydrogenation catalysts derived from “frustrated Lewis pair” (FLP) systems. The range of catalysts uncovered and the applications to reductions of imines, aziridines, enamines, silyl enol ethers, diimines, metallocene derivatives and nitrogen-based heterocycles are described. In addition, FLP aromatic reduction of aniline derivatives to the cyclohexylamine analogs is discussed. The potential applications of these metal-free reductions are considered.

Graphical abstract: “Frustrated Lewis pair” hydrogenations

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The article was received on 16 Feb 2012, accepted on 21 Mar 2012 and first published on 16 Apr 2012

Article type: Perspective
DOI: 10.1039/C2OB25339A
Org. Biomol. Chem., 2012,10, 5740-5746

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    “Frustrated Lewis pair” hydrogenations

    D. W. Stephan, Org. Biomol. Chem., 2012, 10, 5740
    DOI: 10.1039/C2OB25339A

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