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Issue 23, 2012
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A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones

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Abstract

We present here a new, general, solid phase strategy for the synthesis of sequence independent peptidyl-fluoromethyl ketones using standard Fmoc peptide chemistry. Our method is based on the synthesis of bifunctional linkers which allows the incorporation of amino acid fluoromethyl ketone unit at the C-terminal end of peptide sequences. Application of this approach for the synthesis of activity based probes for SENPs is also described.

Graphical abstract: A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones

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Article information


Submitted
13 Jan 2012
Accepted
03 Apr 2012
First published
03 Apr 2012

Org. Biomol. Chem., 2012,10, 4516-4523
Article type
Paper

A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones

G. Roiban, M. Matache, N. D. Hădade and D. P. Funeriu, Org. Biomol. Chem., 2012, 10, 4516
DOI: 10.1039/C2OB25096A

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