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Issue 18, 2012
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Phosphorus containing mixed anhydrides—their preparation, labile behaviour and potential routes to their stabilisation

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Abstract

Simple mixed anhydrides are known to pose synthetic difficulties relating to their thermal lability and ways to stabilise such mixed anhydride systems by relying on either electronic or steric effects were therefore explored. Thus, a series of acyloxyphosphines and acylphosphites derived from either propanoic acid or phenylacetic acid were prepared and their in solution stability assessed. These compounds were, where stability allowed, fully characterised using standard analytical techniques. NMR studies, in particular, unearthed interesting coupling behaviour for a number of the acyloxyphosphines and acylphosphites as well as their rearrangement products which could be linked to their chiral nature. Furthermore, the crystal structures for three of the prepared mixed anhydrides were determined using X-ray crystallography and are reported herein.

Graphical abstract: Phosphorus containing mixed anhydrides—their preparation, labile behaviour and potential routes to their stabilisation

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Publication details

The article was received on 22 Dec 2011, accepted on 02 Mar 2012 and first published on 05 Mar 2012


Article type: Paper
DOI: 10.1039/C2OB07164A
Citation: Org. Biomol. Chem., 2012,10, 3677-3688

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    Phosphorus containing mixed anhydrides—their preparation, labile behaviour and potential routes to their stabilisation

    J. Coetzee, G. R. Eastham, A. M. Z. Slawin and D. J. Cole-Hamilton, Org. Biomol. Chem., 2012, 10, 3677
    DOI: 10.1039/C2OB07164A

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