Issue 6, 2012
From the journal:

Organic & Biomolecular Chemistry

Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate†

Sinem Tuncel,a   Jérémie Fournier-dit-Chabert,b   Florian Albrieux,c   Vefa Ahsen,*a   Sylvie Ducki*b  and  Fabienne Dumoulin*a  

* Corresponding authors

a Department of Chemistry, Gebze Institute of Technology, P.O. Box 141, 41400 Gebze Kocaeli, Turkey
E-mail: ahsen@gyte.edu.tr, fdumoulin@gyte.edu.tr
Fax: +90 262 605 31 01
Tel: +90 262 605 31 06

b Clermont Université, ENSCCF, EA 987, LCHG, BP 10448, Clermont-Ferrand, France
E-mail: sylvie.ducki@univ-bpclermont.fr
Fax: +33 4 73 40 70 08
Tel: +33 4 73 40 71 32

c Centre Commun de Spectrométrie de Masse UMR 5246, CNRS-Université Claude Bernard Lyon 1, Université de Lyon, Bâtiment Curien, 43, bd du 11 Novembre, 69622 Villeurbanne Cedex, France

Abstract

A phthalocyanine–chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(II) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.

Graphical abstract: Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate

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Article information

DOI
https://doi.org/10.1039/C2OB06809E
Article type
Communication
Submitted
28 Oct 2011
Accepted
24 Nov 2011
First published
04 Jan 2012

Org. Biomol. Chem., 2012,10, 1154-1157

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Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate

S. Tuncel, J. Fournier-dit-Chabert, F. Albrieux, V. Ahsen, S. Ducki and F. Dumoulin, Org. Biomol. Chem., 2012, 10, 1154 DOI: 10.1039/C2OB06809E

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