Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

Erika L. Smith; Adrienne S. Brown; Edward Adjaye-Mensah; James N. Wilson

doi:10.1039/C2OB06796J

Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

Erika L. Smith,^a^b Adrienne S. Brown,^a Edward Adjaye-Mensah^a and James N. Wilson*^a

* Corresponding authors

^a Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, USA
E-mail: jnwilson@miami.edu
Fax: +1 305 284 4571
Tel: +1 305 284 2619

^b Present address: Princeton University, 2457 Frist Center, Princeton, USA

Abstract

A series of stilbazolium dimers were synthesized and investigated as sterically demanding ligands targeting the norepinephrine transporter (NET). The environmentally sensitive fluorescence of the dyes enables their use as self-reporting ligands; binding to and displacement from NET can be monitored by fluorescence microscopy.

Supplementary files

Publication details

The article was received on 25 Oct 2011, accepted on 29 Nov 2011 and first published on 30 Nov 2011

Article type: Communication

DOI: 10.1039/C2OB06796J

Citation: Org. Biomol. Chem., 2012,10, 1493-1496

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Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

E. L. Smith, A. S. Brown, E. Adjaye-Mensah and J. N. Wilson, Org. Biomol. Chem., 2012, 10, 1493
DOI: 10.1039/C2OB06796J
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Organic & Biomolecular Chemistry

Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

Abstract

Supplementary files

Publication details

Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

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