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Issue 8, 2012
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Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers†

Erika L. Smith,ab   Adrienne S. Brown,a   Edward Adjaye-Mensaha  and  James N. Wilson*a  
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* Corresponding authors

a Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL, USA
E-mail: jnwilson@miami.edu
Fax: +1 305 284 4571
Tel: +1 305 284 2619

b Present address: Princeton University, 2457 Frist Center, Princeton, NJ, USA

Abstract

A series of stilbazolium dimers were synthesized and investigated as sterically demanding ligands targeting the norepinephrine transporter (NET). The environmentally sensitive fluorescence of the dyes enables their use as self-reporting ligands; binding to and displacement from NET can be monitored by fluorescence microscopy.

Graphical abstract: Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

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Article information

https://doi.org/10.1039/C2OB06796J
Submitted
25 Oct 2011
Accepted
29 Nov 2011
First published
30 Nov 2011
Org. Biomol. Chem., 2012,10, 1493-1496
Article type
Communication
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Probing the functional limits of the norepinephrine transporter with self-reporting, fluorescent stilbazolium dimers

E. L. Smith, A. S. Brown, E. Adjaye-Mensah and J. N. Wilson, Org. Biomol. Chem., 2012, 10, 1493
DOI: 10.1039/C2OB06796J

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