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Issue 10, 2012
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Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block

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Abstract

A concise synthetic route has been developed for the preparation of a constrained peptidomimetic pyrazinone building block. From hydroxy-L-lysine, the desired pyrazinone is obtained in 43% overall yield (6 steps) via an efficient deprotection–double cyclization sequence.

Graphical abstract: Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block

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Publication details

The article was received on 20 Oct 2011, accepted on 05 Jan 2012 and first published on 06 Jan 2012


Article type: Paper
DOI: 10.1039/C2OB06762E
Org. Biomol. Chem., 2012,10, 2003-2007

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    Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block

    V. Gembus, S. Janvier, J. Lecouvé, L. Vaysse-Ludot, J. Brière and V. Levacher, Org. Biomol. Chem., 2012, 10, 2003
    DOI: 10.1039/C2OB06762E

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