Issue 8, 2012
From the journal:

Organic & Biomolecular Chemistry

Organocatalytic enantioselective pyrazol-3-one addition to maleimides: Reactivity and stereochemical course†

Andrea Mazzanti,a   Teresa Calbet,b   Merce Font-Bardia,b   Albert Moyanoc  and  Ramon Rios*cd  

* Corresponding authors

a Department of Organic Chemistry “A. Mangini”, University of Bologna, Viale Risorgimento 4, Bologna, Italy

b Departament de Cristalografia, Mineralogia i Dipòsits Minerals, Universitat de Barcelona, Martí i Franqués s/n, Barcelona, Spain

c Department of Organic Chemistry, Universitat de Barcelona, Martí i Franqués 1-11, Barcelona, Spain

d ICREA Pg. Lluís Companys 23, Barcelona, (Spain)
E-mail: ríos.ramon@icrea.cat
Fax: (+34)933397878

Abstract

The enantioselective synthesis of pyrazol-3-ones has not been extensively studied in organic synthesis. Here in we report the first asymmetric addition of pyrazolones to maleimides catalyzed by bifunctional thiourea catalysts.

Graphical abstract: Organocatalytic enantioselective pyrazol-3-one addition to maleimides: Reactivity and stereochemical course

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Article information

DOI
https://doi.org/10.1039/C2OB06553C
Article type
Paper
Submitted
09 Sep 2011
Accepted
28 Nov 2011
First published
30 Nov 2011

Org. Biomol. Chem., 2012,10, 1645-1652

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Organocatalytic enantioselective pyrazol-3-one addition to maleimides: Reactivity and stereochemical course

A. Mazzanti, T. Calbet, M. Font-Bardia, A. Moyano and R. Rios, Org. Biomol. Chem., 2012, 10, 1645 DOI: 10.1039/C2OB06553C

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