Issue 8, 2012
From the journal:

Organic & Biomolecular Chemistry

Asymmetric hydrogenation of α- or β-acyloxy α,β-unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite†‡

Jinzhu Zhang,a   Kaiwu Dong,a   Zheng Wanga  and  Kuiling Ding*a  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, P.R. China
E-mail: kding@mail.sioc.ac.cn
Fax: +86 21 64166128

Abstract

The Rh(I) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of α- or β-acyloxy α,β-unsaturated phosphonates, providing the corresponding biologically important chiral α- or β-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90–>99% ee).

Graphical abstract: Asymmetric hydrogenation of α- or β-acyloxy α,β-unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite

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Article information

DOI
https://doi.org/10.1039/C1OB06835K
Article type
Paper
Submitted
01 Nov 2011
Accepted
18 Nov 2011
First published
04 Jan 2012

Org. Biomol. Chem., 2012,10, 1598-1601

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Asymmetric hydrogenation of α- or β-acyloxy α,β-unsaturated phosphonates catalyzed by a Rh(I) complex of monodentate phosphoramidite

J. Zhang, K. Dong, Z. Wang and K. Ding, Org. Biomol. Chem., 2012, 10, 1598 DOI: 10.1039/C1OB06835K

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