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Issue 6, 2012
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A general procedure for the synthesis of alkyl- and arylethynyl-1,2,3-triazole-fused dihydroisoquinolines

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Abstract

A general procedure for the synthesis of the title compounds has been devised starting from the available 2-halophenylethyl azides, by means of click reactions with trimethylsilylacetylene or 1-trimethylsilyl-1,3-butadiyne followed by a transition metal-catalyzed functionalization of C–H bond. A further extension of this procedure led us to devise the synthesis of more complex 4,4′-bitriazole-fused dihydroisoquinolines.

Graphical abstract: A general procedure for the synthesis of alkyl- and arylethynyl-1,2,3-triazole-fused dihydroisoquinolines

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Publication details

The article was received on 07 Oct 2011, accepted on 07 Nov 2011 and first published on 17 Nov 2011


Article type: Paper
DOI: 10.1039/C1OB06701J
Org. Biomol. Chem., 2012,10, 1186-1195

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    A general procedure for the synthesis of alkyl- and arylethynyl-1,2,3-triazole-fused dihydroisoquinolines

    V. Fiandanese, S. Maurantonio, A. Punzi and G. G. Rafaschieri, Org. Biomol. Chem., 2012, 10, 1186
    DOI: 10.1039/C1OB06701J

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