Issue 6, 2012
From the journal:

Organic & Biomolecular Chemistry

A general procedure for the synthesis of alkyl- and arylethynyl-1,2,3-triazole-fused dihydroisoquinolines

Vito Fiandanese,*a   Silvia Maurantonio,a   Angela Punzia  and  Giacomo G. Rafaschieria  

* Corresponding authors

a Dipartimento di Chimica, Università di Bari “Aldo Moro”, via Orabona 4, Bari, Italy
E-mail: fianda@chimica.uniba.it
Fax: +39-080-5442075
Tel: +39-080-5442075

Abstract

A general procedure for the synthesis of the title compounds has been devised starting from the available 2-halophenylethyl azides, by means of click reactions with trimethylsilylacetylene or 1-trimethylsilyl-1,3-butadiyne followed by a transition metal-catalyzed functionalization of C–H bond. A further extension of this procedure led us to devise the synthesis of more complex 4,4′-bitriazole-fused dihydroisoquinolines.

Graphical abstract: A general procedure for the synthesis of alkyl- and arylethynyl-1,2,3-triazole-fused dihydroisoquinolines

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C1OB06701J
Article type
Paper
Submitted
07 Oct 2011
Accepted
07 Nov 2011
First published
17 Nov 2011

Org. Biomol. Chem., 2012,10, 1186-1195

Permissions

Request permissions

A general procedure for the synthesis of alkyl- and arylethynyl-1,2,3-triazole-fused dihydroisoquinolines

V. Fiandanese, S. Maurantonio, A. Punzi and G. G. Rafaschieri, Org. Biomol. Chem., 2012, 10, 1186 DOI: 10.1039/C1OB06701J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements