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Issue 6, 2012
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Diversity oriented and chemoenzymatic synthesis of densely functionalized pyrrolidines through a highly diastereoselective Ugi multicomponent reaction

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Abstract

A highly diastereoselective Ugi reaction involving a chiral cyclic imine, two enantiomerically pure isocyanides and various carboxylic acids was employed for the synthesis of polyfunctionalized pyrrolidines. Both chiral substrates have been efficiently prepared by chemoenzymatic methodologies from readily available achiral substrates. This highly convergent approach can find an application in the fragment-based drug discovery process.

Graphical abstract: Diversity oriented and chemoenzymatic synthesis of densely functionalized pyrrolidines through a highly diastereoselective Ugi multicomponent reaction

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Publication details

The article was received on 24 Sep 2011, accepted on 27 Oct 2011 and first published on 03 Nov 2011


Article type: Paper
DOI: 10.1039/C1OB06632C
Citation: Org. Biomol. Chem., 2012,10, 1255-1274

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    Diversity oriented and chemoenzymatic synthesis of densely functionalized pyrrolidines through a highly diastereoselective Ugi multicomponent reaction

    V. Cerulli, L. Banfi, A. Basso, V. Rocca and R. Riva, Org. Biomol. Chem., 2012, 10, 1255
    DOI: 10.1039/C1OB06632C

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