Issue 2, 2012

Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles

Abstract

α,α-Dicyanoolefins react with hydroxylamine to afford 2,3-dihydroisoxazoles (2,3-dihydroisoxazoles can be easily isolated by filtration) in excellent yields under mild and environmentally benign conditions. A one-pot reaction in tandem with an unexpected ring-opening of 2,3-dihydroisoxazoles has been developed as well.

Graphical abstract: Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles

Supplementary files

Article information

Article type
Communication
Submitted
03 Aug 2011
Accepted
27 Sep 2011
First published
27 Sep 2011

Org. Biomol. Chem., 2012,10, 244-247

Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles

P. Li, B. Teng, F. Jin, X. Li, W. Zhu and J. Xie, Org. Biomol. Chem., 2012, 10, 244 DOI: 10.1039/C1OB06318A

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