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Issue 24, 2011
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Divergent synthetic approach to 6′′-modified α-GalCer analogues

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Abstract

A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6′′-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6′′-modified KRN7000 analogues.

Graphical abstract: Divergent synthetic approach to 6′′-modified α-GalCer analogues

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Publication details

The article was received on 23 Jul 2011, accepted on 02 Sep 2011 and first published on 02 Sep 2011


Article type: Paper
DOI: 10.1039/C1OB06235B
Org. Biomol. Chem., 2011,9, 8413-8421

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    Divergent synthetic approach to 6′′-modified α-GalCer analogues

    N. Pauwels, S. Aspeslagh, G. Vanhoenacker, K. Sandra, E. D. Yu, D. M. Zajonc, D. Elewaut, B. Linclau and S. Van Calenbergh, Org. Biomol. Chem., 2011, 9, 8413
    DOI: 10.1039/C1OB06235B

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