Issue 21, 2011

Copper(i)-catalyzed synthesis of 1,3-enynes via coupling between vinyl halides and alkynes or domino coupling of vinyl halides

Abstract

1,3-Enynes were easily prepared from coupling between vinyl halides and alkynes or domino coupling of vinyl halides in the presence of copper iodide. It is noteworthy that the double-bond geometry of the vinyl halides was retained during the reaction. This ligand-free protocol is potentially useful and practical.

Graphical abstract: Copper(i)-catalyzed synthesis of 1,3-enynes via coupling between vinyl halides and alkynes or domino coupling of vinyl halides

Supplementary files

Article information

Article type
Communication
Submitted
20 Jul 2011
Accepted
31 Aug 2011
First published
01 Sep 2011

Org. Biomol. Chem., 2011,9, 7309-7312

Copper(I)-catalyzed synthesis of 1,3-enynes via coupling between vinyl halides and alkynes or domino coupling of vinyl halides

Y. Zhu, T. Li, X. Qu, P. Sun, H. Yang and J. Mao, Org. Biomol. Chem., 2011, 9, 7309 DOI: 10.1039/C1OB06210G

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