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Issue 22, 2011
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A radical cyclization approach to the formal total syntheses of platencin

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Abstract

Two different strategies leading to formal total syntheses of platencin are described. The first strategy involving Claisen rearrangement and radical cyclization provides a rapid access to the core structure of platencin, and also use minimum protective-group operations. The second strategy, a protecting group-free route, utilizes a 6-exo-trig radical cyclization and aldol condensation as key steps leading to the formal synthesis of platencin.

Graphical abstract: A radical cyclization approach to the formal total syntheses of platencin

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Publication details

The article was received on 12 Jul 2011, accepted on 18 Aug 2011 and first published on 18 Aug 2011


Article type: Paper
DOI: 10.1039/C1OB06155K
Org. Biomol. Chem., 2011,9, 7877-7886

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    A radical cyclization approach to the formal total syntheses of platencin

    K. Palanichamy, A. V. Subrahmanyam and K. P. Kaliappan, Org. Biomol. Chem., 2011, 9, 7877
    DOI: 10.1039/C1OB06155K

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